The Battle East of the Tigris on 1 October 331 BCE That Ended the Persian Empire When Alexander the Great Defeated Darius III
Alexander the Great's Macedonian army of approximately 47,000 defeated Darius III's Persian army of approximately 100,000 east of the Tigris river on 1 October 331 BCE. Darius fled the field. The Persian Empire that had existed for two centuries collapsed within months. Darius was murdered by his own satrap nine months later. Alexander died of fever at Babylon four years after that.
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