The First Recorded Bubonic Plague Pandemic in Europe That Killed Up to Half the Population of the Eastern Roman Empire Between 541 and 549 CE
The Plague of Justinian reached Constantinople in spring 542 CE from Egypt and Pelusium. Procopius records a peak mortality of about 5,000 deaths per day in Constantinople. Modern genetic analysis of plague burials at Aschheim in Bavaria confirmed in 2013 that the pathogen was Yersinia pestis — the same bacterium that caused the 14th-century Black Death. The empire-wide death toll is estimated at 25-50 percent of population.
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