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The Black Death — the 1346–1353 plague that killed perhaps half of Europe — arrived in the Mediterranean on Genoese trading ships in October 1347. The ships had picked up the infection at?

From the story
The Great Mortality

Between 1347 and 1351 a pandemic killed somewhere between a third and half of everyone in Europe. Contemporaries called it the Great Mortality. It was the largest single demographic event in recorded human history.

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